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Duodenal biopsies are the most frequently disrupted samples among all the different mucosal types we get from the GI tract. The villi are frequently ripped away from the surface and the biopsies are crushed or otherwise mangled. I get good results educating my clinicians that duodenum needs the most gentle handling of all GI mucosal biopsies when it is transferred from the forceps to the fixative. This might be a useful addition to the introductory comments of this review. Thank you for writing this excellent review!