Congratulations to the awardees!
Best case of the month
Gastric Desmoid Fibromatosis (April 2021)
The authors are:
Jim ChunHao Lee, MD, MPH AP/CP Resident, PGY-3 & Saverio Ligato, MD Attending Pathologist
Travel award 2022:
Rupinder Brar, Albany Medical Center
Congratulations to the 2022 GIPS Abstract Award Winners!
Winner: Beena Ahsan
What is my N-terminus MSH6 antibody missing?
First Runner-up: Nicole Tomm
Follow Up Biopsies in Gastrointestinal Immune Checkpoint Inhibitor Toxicity May Show Markedly Different Inflammatory Patterns Than Initial Injury.
Second Runner-up: Dorukhan Bahceci
Undetected Dysplasia Found in Colectomy Specimens of Patients with Inflammatory Bowel Disease is Often Associated with Non‐Conventional Dysplastic Features, Flat/Invisible Gross Appearance, and Primary Sclerosing Cholangitis.
A 50 year-old-female with past history of pulmonary sarcoidosis, gastroesophageal reflux disease and Helicobacter pylori gastritis underwent a routine screening colonoscopy. Her last colonoscopy 7 years ago was normal. Colonoscopy revealed a sessile polyp measuring 3 mm in the cecum, which was biopsied.
GIPS Case of the Month_Feb-edited
A 19-year-old girl presented with fatigue, fever and protracted bloody diarrhea for 3 weeks.
GIPS Jan 2022_Case of the Month
Please see below to download PDF files of the lectures from the GIPS session at the ASCP 2021 annual meeting, held virtually. The lectures were by Drs. A. Bellizzi and C. Sigel.
BELLIZZI GIPS at ASCP – HER2 Testing in CRC
Biomarker testing on cytology specimens the tubular GI tract 10202021
Thank you to the faculty for sharing their GIPS presentations with the members. Please responsibly use these shared lectures for your learning, and do not forward, replicate, or modify without the permission of the respective faculty member.
A 26 year old male presented with a history of chronic diarrhea and hematochezia. Past medical history was significant for severe immunosuppression due to HIV and HAART therapy noncompliance.
A 74 yo male presented with right lower quadrant tenderness. He denied nausea, vomiting, fevers, and abnormal bowel movements. CT scan revealed a 6 cm mass centered in the right colon. Colonoscopy was unremarkable, and the patient underwent surgical resection.
Dear GIPS Members –
GIPS will be delivering up to date education content on biomarkers at the ASCP Annual Meeting via a virtual lecture series. Please see below for more information on this upcoming session.
DMT517-21 Presented by GIPS:
Updates on Biomarker Testing in Gastrointestinal Malignancies
Jinru Shia, MD
Andrew Bellizzi, MD FASCP
12:30 PM – 1:30 PM EDT on Sunday, October 17
Add to Calendar
Funded by an independent educational grant from Merck Sharp and Dohme Corp.
The recent years have seen the emergence of many highly specific immunohistochemistry biomarkers directed against the protein products of specific genetic alterations in gastrointestinal malignancies. Such markers have improved tumor prognostication and, most importantly, served to direct effective targeted therapies. The effectiveness of tumor biomarkers, however, hinges on optimal testing methodology and accurate interpretation of the testing results. Standardization is therefore key. As the targeted therapies are most utilized in advanced and unresectable malignancies, the available test samples are often small biopsies and not infrequently cytology materials, which calls for further attention in test optimization and standardization. The aim of this session is to provide an update on the testing of tumor biomarkers in GI malignancies, with an emphasis on HER2 testing in colorectal carcinoma, and the unique aspects of utilizing minimal material including cytology material as test samples.
- To gain an overview of the newly emerged and emerging prognostic and predicative biomarkers in gastrointestinal malignancies.
- To achieve an improved understanding of HER2 testing in colorectal cancer, and be able to address the frequently encountered questions relate to this test.
- To know the pitfalls and caveats in biomarker testing with minimal tissue samples including cytology materials.
A 33-year-old female with history of gastroesophageal reflux disease and H. pylori gastritis presented with epigastric pain and dysphagia. Endoscopic ultrasound demonstrated a 2.5 cm mass located on the lesser curvature and originating from within the muscularis propria.
A 19-year-old woman presented to her gastroenterologist with a chief complaint of chronic abdominal pain. Her past medical history included allergic rhinitis, anxiety, gastroesophageal reflux disease, iron deficiency anemia, migraines, and an eating disorder. Her medications included amitriptyline, gabapentin, acetaminophen, esomeprazole magnesium, ferrous sulfate, fluticasone propionate nasal spray, hyoscyamine, melatonin, and omeprazole. Laboratory tests for tissue transglutaminase IgA and deaminated gliadin were negative. Serum IgA levels were normal. She underwent esophagogastroduodenoscopy which showed a normal-appearing esophagus, bilious-appearing fluid in the stomach, moderate erythema of the gastric antrum and body with significant nodularity of the gastric body, and a normal appearing duodenum. Biopsies were obtained of the esophagus, gastric antrum and body, and duodenum. The biopsies of the esophagus, antrum, and duodenum were normal. Endoscopic photos of the gastric body and photomicrographs of the H&E-stained slides of the gastric body are seen below. Immunohistochemical stains for gastrin and H. pylori and Congo red stain for amyloid on the biopsies of the gastric body were negative. Prior biopsies of her colon were normal.